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Science and Technology thread

Ive been storing my veggies in the crisper for years, I don't get the big deal
 
Me: the CRISPR experiment did not work as intended.
JML: let me explain to you what CRISPR is and my vast knowledge of how it works without once discussing the findings of the experiment, which the researchers themselves describe as surprising.

It's kinda nuts you don't even acknowledge the point being made and are getting hooked up on one word and using that to assume I don't understand anything about CRISPR. Then you try to show off your vast Wikipedia like knowledge.

If you move from your high perch, my point is still valid. Fine then replace gene with gene edit or mutation. It doesn't matter for what I was sharing. The experimenters tried to put in lab made fragments to insert/replace in the area clipped. Those fragments didn't take and instead the embryos copied from the other parents gene. There are implications then for what kind of diseases can be treated as the article very well lays out.

It's no wonder nobody likes you.
 
"Me:(Not to burst your CRISPR bubble) the CRISPR experiment did not work as intended."

Based upon the original Nature article I'm saying that the fundamental premise of this statement and in part the lay article is not really true.

The experiment worked as the investigators hypothesized and they actually discovered a means to avoid a significant problem in genetic repair of embryos.

1. Genetic repair in embryos can be carried out successfully for genes that are targeted

2. Using targeting techniques, they managed to eliminate the risk of "mosaics," embryos that have different cells with genes that are not completely identical (some remained, some not). This is potentially huge in the long-term potential for CRISPR.

3. HOWEVER, there is still the problem I mentioned of "off-target effects" or editing away from the target gene, that remains even in embryos. The authors were well aware and quantified this expected issue, and this remains the most challenging problem to solve with CRIPSR.

There is a mistaken public perception that CRISPR can produce "designer babies." That's not what it does, and the authors were under no such illusion.

fwiw, we do knockdown gene experiments and colleagues use CRISPR to battle neuromuscular disease.
 
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Again missing the point and arguing something completely different. I really don't know how to spell it out anymore clearly then I did. Either you are obtuse or trolling or both. But as mentioned previously so many people dislike you so much here and this shows why.


Also I'm not even talking about off target effects,which I agree is an issue, yet you continue to bring it up as if I'm arguing about that. Spoiler alert: I'm not.

You are the reason Trump won.
 
I am looking to purchase a new laptop. Said laptop will be used almost solely for remoting into work PCs from my home and for storing pics/vids. We don't do any gaming at all. My wife will do minimal editing of pics/vids. We will do very minimal web surfing as well since we use iphones and iPad for that. I need some recommendations. I've spoken with two IT professionals, and they both recommend at least 16GB RAM, SSD or at least boot SSD with high GB HDD, and dedicated graphics. I go to Dell, HP, wherever and try to put this thing together, and I'm creeping up to $1000 which seems way too expensive for how little I actually want to do with the thing. It's 2017, and I figured I could get a decent laptop for the price of a toaster oven. But I'll spend the money if I have to.

Any gurus here have an opinion for me?

Also, I should note that Mac vs PC doesn't matter so much to me. Mac helps keep us from giving it AIDS, but PC's price point is typically better plus in my limited experience it's easier using PC to remote into work PCs.
 
physicsfactor said:
I am looking to purchase a new laptop. Said laptop will be used almost solely for remoting into work PCs from my home and for storing pics/vids. We don't do any gaming at all. My wife will do minimal editing of pics/vids. We will do very minimal web surfing as well since we use iphones and iPad for that. I need some recommendations. I've spoken with two IT professionals, and they both recommend at least 16GB RAM, SSD or at least boot SSD with high GB HDD, and dedicated graphics. I go to Dell, HP, wherever and try to put this thing together, and I'm creeping up to $1000 which seems way too expensive for how little I actually want to do with the thing. It's 2017, and I figured I could get a decent laptop for the price of a toaster oven. But I'll spend the money if I have to.

Any gurus here have an opinion for me?

Also, I should note that Mac vs PC doesn't matter so much to me. Mac helps keep us from giving it AIDS, but PC's price point is typically better plus in my limited experience it's easier using PC to remote into work PCs.
Click to expand...

It's hard to go wrong with a Lenovo ThinkPad, but I'm not sure you can get those specs for less than $1K

Acer Aspires are surprisingly not bad now, but I'm not sure if they've got anything with those specs.
 
I know it's dumb because it was a decade ago, but a bad experience with an Acer will always make it a hard sell for me.
 
Yeah, they were the cheap crap that places like Best Buy used to push, but they've improved a lot.

Take a look at Amazon and Newegg.com, the reviews (and Newegg's search options) might be of help.
 
The most telling indicator of reliability on a laptop is the cost of the 3-year warranty. I bought a crappy Dell where the 3-year warranty was 30% of the cost of the laptop. That should have tipped me off, and sure enough, it died maybe two weeks after the warranty ended. My latest Lenovo Thinkpad T-series was bought in 2011 and is still going strong; I've put in expanded RAM but that's it. Its 3-year warranty was only 12% of the base cost. That tells me a lot about what the company believes its 3-year failure rate is.

So even if you don't plan to get the extended warranty, throw it in your cart and see how much it is. Don't buy a laptop that charges more than 20% or so for the 3-year warranty.
 
I have no experience with Lenovo products, but I see they've been getting great reviews.

Good thought on the extended warranty price. Makes sense. Thanks, guys.
 
I have a Lenovo Yoga 700 that I bought last year. It's the glitchiest thing I've ever used. I had to turn the touch screen off permanently to prevent the computer from "touching" different areas of the screen by itself. It also randomly tells me it needs to restart and won't allow me time to save files. Since I bought it for work and use it 95% for Excel spreadsheets, that's a big problem for me.

Maybe it's just a crap model, though. It wasn't the most expensive one at Best Buy at all.
 
Manufacturer quality varies a LOT between their business lines and their entry-level offerings. That's why general manufacturer reputation is not really enough information. For example, my Dell Inspiron was a dud, but a lot of people like the Latitudes, which seem to last a lot longer. Our lab bought a number of Yogas from Lenovo and they were terrible indeed.
 
Helped a guy save his iphone from ransomware. Had never seen ransomware on an iphone before but was able to outsmart it enough to save his phone from being a paperweight. Recovered all contacts and all photos that had been backed up. Suck it ransomware.
 
When this becomes the norm and there are no more construction jobs, Obama will somehow be blamed.

 


Entire island about to be revamped to run on solar power under the Trump administration. Wonder if he levies economic punishment on Tesla so that only electric/coal companies can work on this project instead, with great urgency to fix Puerto Rico now that green energy is threatening to get involved.
 

Never forget listening to embarrassingly enjoyable things like Butthole Surfers, TLC and The Presidents of the United States of America downloaded from Napster or Limewire while taking 15 minutes to decide what to put in your AIM away message before leaving your room for 5 minutes.
 
When someone downloads a gigantic super high quality movie, will this person be able to watch that movie at its highest possible definition or quality on any laptop, or does this person's laptop need to be capable of a certain resolution?

I can't tell the difference most of the time between 720p and 1080p downloads, but this may be because of my eyes rather than my laptop being incapable (it's old). I also don't see any laptops being advertised as being able to show Bluray or Dolby Atmos quality movies, so I assume it might not be relevant.

I am seeing some enormous movie files out there that are supposedly in Atmos quality now. Not going to obtain them if I can't make use of them.
 
Check the resolution of you monitor. The smaller number will correlate to either 720/1080/1440/etc. That's the best quality your laptop can reproduce.
 
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